Functional diversity and co-operativity between subclonal populations of paediatric glioblastoma and diffuse intrinsic pontine glioma cells

The failure to develop effective therapies for paediatric glioblastoma (pGBM) and diffuse intrinsic pontine glioma (DIPG) is in part due to their intrinsic heterogeneity. We aimed to quantitatively map assess the extent to which this was present in these tumours through subclonal genomic analyses, a...

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Bibliografske podrobnosti
izdano v:Nat Med
Main Authors: Vinci, Mara, Burford, Anna, Molinari, Valeria, Kessler, Ketty, Popov, Sergey, Clarke, Matthew, Taylor, Kathryn R, Pemberton, Helen, Lord, Christopher J, Gutteridge, Alice, Forshew, Tim, Carvalho, Diana, Marshall, Lynley V, Qin, Elizabeth Y, Ingram, Wendy J, Moore, Andrew S, Ng, Ho-Keung, Trabelsi, Saoussen, Brahim, Dorra H’mida-Ben, Entz-Werle, Natacha, Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C, Bridges, Leslie R, Martin, Andrew J, Al-Sarraj, Safa, Chandler, Christopher, Sunol, Mariona, Mora, Jaume, de Torres, Carmen, Cruz, Ofelia, Carcaboso, Angel M, Monje, Michelle, Mackay, Alan, Jones, Chris
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086334/
https://ncbi.nlm.nih.gov/pubmed/29967352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0086-7
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