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Genetic Network Complexity Shapes Background-Dependent Phenotypic Expression
The phenotypic consequences of a given mutation can vary across individuals. This so-called “background effect” is widely observed, from mutant fitness of loss-of-function variants in model organisms to variable disease penetrance and expressivity in humans; however, the underlying genetic basis oft...
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| Publicado no: | Trends Genet |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6085889/ https://ncbi.nlm.nih.gov/pubmed/29903533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2018.05.006 |
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