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Genetic Network Complexity Shapes Background-Dependent Phenotypic Expression

The phenotypic consequences of a given mutation can vary across individuals. This so-called “background effect” is widely observed, from mutant fitness of loss-of-function variants in model organisms to variable disease penetrance and expressivity in humans; however, the underlying genetic basis oft...

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Foilsithe in:Trends Genet
Main Authors: Hou, Jing, van Leeuwen, Jolanda, Andrews, Brenda J., Boone, Charles
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085889/
https://ncbi.nlm.nih.gov/pubmed/29903533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2018.05.006
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