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Interleukin-7 enables antibody responses to bacterial polysaccharides by promoting B cell antigen receptor diversity

Polysaccharide vaccines such as the Vi polysaccharide of Salmonella enterica serovar Typhi induce efficient antibody responses in adults, but not in young children. The reasons for this difference are not understood. Interleukin-7 (IL-7) dependency in B cell development increases progressively with...

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Udgivet i:J Immunol
Main Authors: Dickinson, Gregory S., Levenson, Eric A., Walker, Justin A., Kearney, John F., Alugupalli, Kishore R.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085875/
https://ncbi.nlm.nih.gov/pubmed/30006375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800162
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