Terminal Deoxynucleotidyl Transferase Is Not Required for Antibody Response to Polysaccharide Vaccines against Streptococcus pneumoniae and Salmonella enterica Serovar Typhi

B cell antigen receptor (BCR) diversity increases by several orders of magnitude due to the action of terminal deoxynucleotidyl transferase (TdT) during V(D)J recombination. Unlike adults, infants have limited BCR diversity, in part due to reduced expression of TdT. Since human infants and young mic...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Belde, Vivek, Cravens, Matthew P., Gulandijany, Dania, Walker, Justin A., Palomo-Caturla, Isabel, Alugupalli, Akhil S., Sandilya, Vijay K., Mahmoud, Tamer, Bäumler, Andreas J., Kearney, John F., Alugupalli, Kishore R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105908/
https://ncbi.nlm.nih.gov/pubmed/29967094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00211-18
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