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Determining the structural and energetic basis of allostery in a de novo designed metalloprotein assembly

Despite significant progress in protein design, the construction of protein assemblies that display complex functions (e.g., catalysis or allostery) remains a significant challenge. We recently reported the de novo construction of an allosteric supramolecular protein assembly (Zn-(C38/C81/C96)R1(4))...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Churchfield, Lewis A., Alberstein, Robert G., Williamson, Laura M., Tezcan, F. Akif
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085756/
https://ncbi.nlm.nih.gov/pubmed/29996654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b05812
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