IL-33 Initiates Vascular Remodelling in Hypoxic Pulmonary Hypertension by up-Regulating HIF-1α and VEGF Expression in Vascular Endothelial Cells

IL-33 may play a role in the vascular remodelling of hypoxic pulmonary hypertension (PH) but the precise mechanisms are still unclear. We hypothesized that hypoxia promotes expression of IL-33 and its receptor ST2 on vascular endothelial cells, which in turn leads to dysfunction of vascular endothel...

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Bibliographische Detailangaben
Veröffentlicht in:EBioMedicine
Hauptverfasser: Liu, Jie, Wang, Wang, Wang, Lei, Chen, Shihao, Tian, Bo, Huang, Kewu, Corrigan, Chris J., Ying, Sun, Wang, Wei, Wang, Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085568/
https://ncbi.nlm.nih.gov/pubmed/29921553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.06.003
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