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Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1
Transcriptional factors ETS1/2 and p52 synergize downstream of non-canonical NF-κB signaling to drive reactivation of the −146C>T mutant TERT promoter in multiple cancer types, but the mechanism underlying this cooperativity remains unknown. Here we report the crystal structure of a ternary p52/E...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6085347/ https://ncbi.nlm.nih.gov/pubmed/30093619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05644-0 |
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