Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1

Transcriptional factors ETS1/2 and p52 synergize downstream of non-canonical NF-κB signaling to drive reactivation of the −146C>T mutant TERT promoter in multiple cancer types, but the mechanism underlying this cooperativity remains unknown. Here we report the crystal structure of a ternary p52/E...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Xu, Xueyong, Li, Yinghui, Bharath, Sakshibeedu R., Ozturk, Mert Burak, Bowler, Matthew W., Loo, Bryan Zong Lin, Tergaonkar, Vinay, Song, Haiwei
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085347/
https://ncbi.nlm.nih.gov/pubmed/30093619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05644-0
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