Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity

The early-life intestinal microbiota plays a key role in shaping host immune system development. We found that a single early-life antibiotic course (1PAT) accelerated type 1 diabetes (T1D) development in male NOD mice. The single course had deep and persistent effects on the intestinal microbiome,...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Zhang, Xue-Song, Li, Jackie, Krautkramer, Kimberly A, Badri, Michelle, Battaglia, Thomas, Borbet, Timothy C, Koh, Hyunwook, Ng, Sandy, Sibley, Rachel A, Li, Yuanyuan, Pathmasiri, Wimal, Jindal, Shawn, Shields-Cutler, Robin R, Hillmann, Ben, Al-Ghalith, Gabriel A, Ruiz, Victoria E, Livanos, Alexandra, van ‘t Wout, Angélique B, Nagalingam, Nabeetha, Rogers, Arlin B, Sumner, Susan Jenkins, Knights, Dan, Denu, John M, Li, Huilin, Ruggles, Kelly V, Bonneau, Richard, Williamson, R Anthony, Rauch, Marcus, Blaser, Martin J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Immunology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085123/
https://ncbi.nlm.nih.gov/pubmed/30039798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37816
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