Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention

BACKGROUND: Stress is the most commonly reported migraine trigger. Dynorphin, an endogenous opioid peptide acting preferentially at kappa opioid receptors (KORs), is a key mediator of stress responses. The aim of this study was to use an injury-free rat model of functional cephalic pain with feature...

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Detalhes bibliográficos
Publicado no:Cephalalgia
Main Authors: Xie, Jennifer Y, Felice, Milena De, Kopruszinski, Caroline M, Eyde, Nathan, LaVigne, Justin, Remeniuk, Bethany, Hernandez, Pablo, Yue, Xu, Goshima, Naomi, Ossipov, Michael, King, Tamara, Streicher, John M, Navratilova, Edita, Dodick, David, Rosen, Hugh, Roberts, Ed, Porreca, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085081/
https://ncbi.nlm.nih.gov/pubmed/28376659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0333102417702120
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