Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit

In the small intestine, type 2 responses are regulated by a signaling circuit that involves tuft cells and group 2 innate lymphoid cells (ILC2). Here we identified the microbial metabolite succinate as an activating ligand for small intestinal (SI) tuft cells. Sequencing analyses of tuft cells isola...

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Publicado en:Immunity
Autores principales: Nadjsombati, Marija S., McGinty, John W., Lyons-Cohen, Miranda R., Jaffe, James B., DiPeso, Lucian, Schneider, Christoph, Miller, Corey N., Pollack, Joshua L., Gowda, G.A. Nagana, Fontana, Mary F., Erle, David J., Anderson, Mark S., Locksley, Richard M., Raftery, Daniel, von Moltke, Jakob
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6084797/
https://ncbi.nlm.nih.gov/pubmed/30021144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.06.016
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