Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit

In the small intestine, type 2 responses are regulated by a signaling circuit that involves tuft cells and group 2 innate lymphoid cells (ILC2). Here we identified the microbial metabolite succinate as an activating ligand for small intestinal (SI) tuft cells. Sequencing analyses of tuft cells isola...

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發表在:Immunity
Main Authors: Nadjsombati, Marija S., McGinty, John W., Lyons-Cohen, Miranda R., Jaffe, James B., DiPeso, Lucian, Schneider, Christoph, Miller, Corey N., Pollack, Joshua L., Gowda, G.A. Nagana, Fontana, Mary F., Erle, David J., Anderson, Mark S., Locksley, Richard M., Raftery, Daniel, von Moltke, Jakob
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6084797/
https://ncbi.nlm.nih.gov/pubmed/30021144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.06.016
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