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Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit
In the small intestine, type 2 responses are regulated by a signaling circuit that involves tuft cells and group 2 innate lymphoid cells (ILC2). Here we identified the microbial metabolite succinate as an activating ligand for small intestinal (SI) tuft cells. Sequencing analyses of tuft cells isola...
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| 發表在: | Immunity |
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| Main Authors: | , , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6084797/ https://ncbi.nlm.nih.gov/pubmed/30021144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.06.016 |
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