A Mechanistic Computational Model Reveals That Plasticity of CD4(+) T Cell Differentiation Is a Function of Cytokine Composition and Dosage

CD4(+) T cells provide cell-mediated immunity in response to various antigens. During an immune response, naïve CD4(+) T cells differentiate into specialized effector T helper (Th1, Th2, and Th17) cells and induced regulatory (iTreg) cells based on a cytokine milieu. In recent studies, complex pheno...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Physiol
Egile Nagusiak: Puniya, Bhanwar Lal, Todd, Robert G., Mohammed, Akram, Brown, Deborah M., Barberis, Matteo, Helikar, Tomáš
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2018
Gaiak:
Physiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6083813/
https://ncbi.nlm.nih.gov/pubmed/30116195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00878
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