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Systems Perturbation Analysis of a Large-Scale Signal Transduction Model Reveals Potentially Influential Candidates for Cancer Therapeutics

Dysregulation in signal transduction pathways can lead to a variety of complex disorders, including cancer. Computational approaches such as network analysis are important tools to understand system dynamics as well as to identify critical components that could be further explored as therapeutic tar...

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Detalhes bibliográficos
Publicado no:Front Bioeng Biotechnol
Main Authors: Puniya, Bhanwar Lal, Allen, Laura, Hochfelder, Colleen, Majumder, Mahbubul, Helikar, Tomáš
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750464/
https://ncbi.nlm.nih.gov/pubmed/26904540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2016.00010
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