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Systems Perturbation Analysis of a Large-Scale Signal Transduction Model Reveals Potentially Influential Candidates for Cancer Therapeutics

Dysregulation in signal transduction pathways can lead to a variety of complex disorders, including cancer. Computational approaches such as network analysis are important tools to understand system dynamics as well as to identify critical components that could be further explored as therapeutic tar...

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Bibliografische gegevens
Gepubliceerd in:Front Bioeng Biotechnol
Hoofdauteurs: Puniya, Bhanwar Lal, Allen, Laura, Hochfelder, Colleen, Majumder, Mahbubul, Helikar, Tomáš
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750464/
https://ncbi.nlm.nih.gov/pubmed/26904540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2016.00010
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