Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: Potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia

Hoxa9 and Meis1a are homeodomain transcription factors that heterodimerize on DNA and are down-regulated during normal myeloid differentiation. Hoxa9 and Meis1a cooperate to induce acute myeloid leukemia (AML) in mice, and are coexpressed in human AML. Despite their cooperativity in leukemogenesis,...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Calvo, Katherine R., Knoepfler, Paul S., Sykes, David B., Pasillas, Martina P., Kamps, Mark P.
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2001
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60834/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11687616/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.231115398
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