Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: Potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia

Hoxa9 and Meis1a are homeodomain transcription factors that heterodimerize on DNA and are down-regulated during normal myeloid differentiation. Hoxa9 and Meis1a cooperate to induce acute myeloid leukemia (AML) in mice, and are coexpressed in human AML. Despite their cooperativity in leukemogenesis,...

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Библиографические подробности
Главные авторы: Calvo, Katherine R., Knoepfler, Paul S., Sykes, David B., Pasillas, Martina P., Kamps, Mark P.
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 2001
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC60834/
https://ncbi.nlm.nih.gov/pubmed/11687616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.231115398
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