STF-083010, an inhibitor of XBP1 splicing, attenuates acute renal failure in rats by suppressing endoplasmic reticulum stress-induced apoptosis and inflammation

Endoplasmic reticulum (ER) stress is one of the driving forces of ischemia/reperfusion (IR)-induced acute renal failure (ARF). STF-083010, an inhibitor of the endonuclease activity of inositol-requiring enzyme-1 (IRE1), has the potential to block the initiation of a prolonged unfolded protein respon...

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Pubblicato in:Exp Anim
Autori principali: Liu, Lei, Xu, Lu, Zhang, Shaoqing, Wang, Dong, Dong, Guoxia, Chen, Hanwen, Li, Xinjian, Shu, Chi, Wang, Rong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Japanese Association for Laboratory Animal Science 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6083033/
https://ncbi.nlm.nih.gov/pubmed/29695649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.17-0131
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