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CRISPR-Based Methods for High-Throughput Annotation of Regulatory DNA

Developments in CRISPR/Cas9-based technologies provide a new paradigm in functional screening of the genome. Conventional screening methods have focused on high-throughput perturbations of the protein-coding genome with technologies such as RNAi. However, equivalent methods for perturbing the non-co...

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Dettagli Bibliografici
Pubblicato in:Curr Opin Biotechnol
Autori principali: Klann, Tyler S., Black, Joshua B., Gersbach, Charles A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082715/
https://ncbi.nlm.nih.gov/pubmed/29500989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.copbio.2018.02.004
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