Autophagy regulates the liver clock and glucose metabolism by degrading CRY1

The circadian clock coordinates behavioral and circadian cues with availability and utilization of nutrients. Proteasomal degradation of clock repressors, e.g., cryptochrome (CRY)1 maintains periodicity. Whether macroautophagy, a quality control pathway, degrades circadian proteins remains unknown....

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發表在:Cell Metab
Main Authors: Toledo, Miriam, Batista-Gonzalez, Ana, Merheb, Emilio, Aoun, Marie Louise, Tarabra, Elena, Feng, Daorong, Sarparanta, Jaakko, Merlo, Paola, Botrè, Francesco, Schwartz, Gary J., Pessin, Jeffrey E., Singh, Rajat
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082686/
https://ncbi.nlm.nih.gov/pubmed/29937374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.05.023
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