Microglial pannexin-1 channel activation is a spinal determinant of joint pain

Chronic joint pain such as mechanical allodynia is the most debilitating symptom of arthritis, yet effective therapies are lacking. We identify the pannexin-1 (Panx1) channel as a therapeutic target for alleviating mechanical allodynia, a cardinal sign of arthritis. In rats, joint pain caused by int...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Mousseau, Michael, Burma, Nicole E., Lee, Kwan Yeop, Leduc-Pessah, Heather, Kwok, Charlie H. T., Reid, Allison R., O’Brien, Melissa, Sagalajev, Boriss, Stratton, Jo Anne, Patrick, Natalya, Stemkowski, Patrick L., Biernaskie, Jeff, Zamponi, Gerald W., Salo, Paul, McDougall, Jason J., Prescott, Steven A., Matyas, John R., Trang, Tuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082646/
https://ncbi.nlm.nih.gov/pubmed/30101191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aas9846
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