Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer’s disease: a cohort study

BACKGROUND: Alzheimer’s disease is characterized by aggregated β-amyloid and tau proteins, but the clinical presentations and patterns of brain atrophy vary substantially. A part of this heterogeneity may be linked to the risk allele APOE ε4. The spread of tau pathology is related to atrophy and cog...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Mattsson, Niklas, Ossenkoppele, Rik, Smith, Ruben, Strandberg, Olof, Ohlsson, Tomas, Jögi, Jonas, Palmqvist, Sebastian, Stomrud, Erik, Hansson, Oskar
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6081879/
https://ncbi.nlm.nih.gov/pubmed/30086796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-018-0403-x
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