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Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport

INTRODUCTION: The mammalian SPS1-related proline/alanine-rich serine-threonine kinase SPAK (STK39) modulates the transport across and between epithelial cells in response to environmental stimuli such osmotic stress and inflammation. Research over the last decade has established a central role for S...

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Publicado en:Expert Opin Ther Targets
Main Authors: Zhang, Jinwei, Karimy, Jason K., Delpire, Eric, Kahle, Kristopher T.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6081737/
https://ncbi.nlm.nih.gov/pubmed/28679296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14728222.2017.1351949
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