Using flexible loop mimetics to extend Φ-value analysis to secondary structure interactions

Chemical synthesis allows the incorporation of nonnatural amino acids into proteins that may provide previously untried probes of their folding pathway and thermodynamic stability. We have used a flexible thioether linker as a loop mimetic in the human yes kinase-associated protein (YAP 65) WW domai...

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Detalhes bibliográficos
Main Authors: Ferguson, Neil, Pires, José Ricardo, Toepert, Florian, Johnson, Christopher M., Pan, Yong Ping, Volkmer-Engert, Rudolf, Schneider-Mergener, Jens, Daggett, Valerie, Oschkinat, Hartmut, Fersht, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC60815/
https://ncbi.nlm.nih.gov/pubmed/11687614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221467398
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