Design and MinION testing of a nanopore targeted gene sequencing panel for chronic lymphocytic leukemia

We report a customized gene panel assay based on multiplex long-PCR followed by third generation sequencing on nanopore technology (MinION), designed to analyze five frequently mutated genes in chronic lymphocytic leukemia (CLL): TP53, NOTCH1, BIRC3, SF3B1 and MYD88. For this purpose, 12 patients we...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Orsini, Paola, Minervini, Crescenzio F., Cumbo, Cosimo, Anelli, Luisa, Zagaria, Antonella, Minervini, Angela, Coccaro, Nicoletta, Tota, Giuseppina, Casieri, Paola, Impera, Luciana, Parciante, Elisa, Brunetti, Claudia, Giordano, Annamaria, Specchia, Giorgina, Albano, Francesco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6081477/
https://ncbi.nlm.nih.gov/pubmed/30087429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30330-y
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge