An orally-active adiponectin receptor agonist mitigates cutaneous fibrosis, inflammation and microvascular pathology in a murine model of systemic sclerosis

The hallmarks of systemic sclerosis (SSc) are autoimmunity, microangiopathy and fibrosis. Skin fibrosis is accompanied by attrition of the dermal white adipose tissue layer, and alterations in the levels and function of adiponectin. Since these findings potentially implicate adiponectin in the patho...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Yamashita, Takashi, Lakota, Katja, Taniguchi, Takashi, Yoshizaki, Ayumi, Sato, Shinichi, Hong, Wen, Zhou, Xingchun, Sodin-Semrl, Snezn, Fang, Feng, Asano, Yoshihide, Varga, John
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6081386/
https://ncbi.nlm.nih.gov/pubmed/30087356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29901-w
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