Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

Pharmacologic arm-selective unfolded protein response (UPR) signaling pathway activation is emerging as a promising strategy to ameliorate imbalances in endoplasmic reticulum (ER) proteostasis implicated in diverse diseases. The small molecule N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide (147) w...

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Bibliographische Detailangaben
Veröffentlicht in:eLife
Hauptverfasser: Paxman, Ryan, Plate, Lars, Blackwood, Erik A, Glembotski, Chris, Powers, Evan T, Wiseman, R Luke, Kelly, Jeffery W
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2018
Schlagworte:
Biochemistry and Chemical Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080950/
https://ncbi.nlm.nih.gov/pubmed/30084354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37168
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