Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice

Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by progressive pulmonary artery (PA) remodeling. T helper 2 cell (Th2) immune response is involved in PA remodeling during PAH progression. Here, we found that CRTH2 (chemoattractant receptor homologous molecule expres...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Chen, Guilin, Zuo, Shengkai, Tang, Juan, Zuo, Caojian, Jia, Daile, Liu, Qian, Liu, Guizhu, Zhu, Qian, Wang, Yuanyang, Zhang, Jian, Shen, Yujun, Chen, Dongrui, Yuan, Ping, Qin, Zhiqiang, Ruan, Chengchao, Ye, Jue, Wang, Xiao-Jian, Zhou, Yuping, Gao, Pingjin, Zhang, Peng, Liu, Jinming, Jing, Zhi-Cheng, Lu, Ankang, Yu, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080901/
https://ncbi.nlm.nih.gov/pubmed/29970474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171767
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