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HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation
Several animal viruses inhibit host protein synthesis, but only some members of the picornavirus group are known to do so by cleaving translation initiation factor eIF4G. Here we report that infection of human CD4(+) cells with HIV-1 also leads to proteolysis of eIF4G and profound inhibition of cell...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC60808/ https://ncbi.nlm.nih.gov/pubmed/11606767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.231343498 |
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