HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation

Several animal viruses inhibit host protein synthesis, but only some members of the picornavirus group are known to do so by cleaving translation initiation factor eIF4G. Here we report that infection of human CD4(+) cells with HIV-1 also leads to proteolysis of eIF4G and profound inhibition of cell...

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Argitaratua izan da:	Proc Natl Acad Sci U S A
Egile Nagusiak:	Ventoso, Iván, Blanco, Raquel, Perales, Celia, Carrasco, Luis
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	National Academy of Sciences 2001
Gaiak:	Biological Sciences
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60808/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11606767/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.231343498
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