The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics

Protein farnesyltransferase (FTase) catalyzes the attachment of a farnesyl lipid group to the cysteine residue located in the C-terminal tetrapeptide of many essential signal transduction proteins, including members of the Ras superfamily. Farnesylation is essential both for normal functioning of th...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Long, Stephen B., Hancock, Paula J., Kral, Astrid M., Hellinga, Homme W., Beese, Lorena S.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60805/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11687658/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.241407898
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