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Cyclic and Lasso Peptides: Sequence Determination, Topology Analysis, and Rotaxane Formation
A broadly-applicable chemical cleavage methodology to facilitate MS/MS sequencing was developed for macrocyclic and lasso peptides, which holds promise as exciting new therapeutics. Existing methods such as Edman degradation, CNBr cleavage, and enzymatic digestion are either limited in scope or comp...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6080247/ https://ncbi.nlm.nih.gov/pubmed/29645322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201801299 |
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