Efficient Non-viral Gene Delivery into Human Hematopoietic Stem Cells by Minicircle Sleeping Beauty Transposon Vectors

The Sleeping Beauty (SB) transposon system is a non-viral gene delivery platform that combines simplicity, inexpensive manufacture, and favorable safety features in the context of human applications. However, efficient correction of hematopoietic stem and progenitor cells (HSPCs) with non-viral vect...

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Pubblicato in:Mol Ther
Autori principali: Holstein, Marta, Mesa-Nuñez, Cristina, Miskey, Csaba, Almarza, Elena, Poletti, Valentina, Schmeer, Marco, Grueso, Esther, Ordóñez Flores, Juan Carlos, Kobelt, Dennis, Walther, Wolfgang, Aneja, Manish K., Geiger, Johannes, Bonig, Halvard B., Izsvák, Zsuzsanna, Schleef, Martin, Rudolph, Carsten, Mavilio, Fulvio, Bueren, Juan A., Guenechea, Guillermo, Ivics, Zoltán
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2018
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079369/
https://ncbi.nlm.nih.gov/pubmed/29503198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.01.012
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