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Directed evolution of CRISPR-Cas9 to increase its specificity
The use of CRISPR-Cas9 as a therapeutic reagent is hampered by its off-target effects. Although rationally designed S. pyogenes Cas9 (SpCas9) variants that display higher specificities than the wild-type SpCas9 protein are available, these attenuated Cas9 variants are often poorly efficient in human...
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| Vydáno v: | Nat Commun |
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| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6078992/ https://ncbi.nlm.nih.gov/pubmed/30082838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05477-x |
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