Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin

Aggf1 is the first gene identified for Klippel-Trenaunay syndrome (KTS), and encodes an angiogenic factor. However, the in vivo roles of Aggf1 are incompletely defined. Here we demonstrate that Aggf1 is essential for both physiological angiogenesis and pathological tumour angiogenesis in vivo. Two l...

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Udgivet i:Hum Mol Genet
Main Authors: Zhang, Teng, Yao, Yufeng, Wang, Jingjing, Li, Yong, He, Ping, Pasupuleti, Vinay, Hu, Zhengkun, Jia, Xinzhen, Song, Qixue, Tian, Xiao-Li, Hu, Changqing, Chen, Qiuyun, Wang, Qing Kenneth
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078640/
https://ncbi.nlm.nih.gov/pubmed/27522498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw273
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