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Synonymous nucleotide modification of the KCNH2 gene affects both mRNA characteristics and translation of the encoded hERG ion channel

Synonymous nucleotide variation is increasingly recognized as a factor than can affect protein expression, but the underlying mechanisms are incompletely understood. Here, we investigated whether synonymous changes could affect expression of the potassium voltage-gated channel subfamily H member 2 (...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Bertalovitz, Alexander C., Badhey, Marika L. Osterbur, McDonald, Thomas V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078446/
https://ncbi.nlm.nih.gov/pubmed/29907571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001805
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