A 5-formyltetrahydrofolate cycloligase paralog from all domains of life: comparative genomic and experimental evidence for a cryptic role in thiamin metabolism

A paralog (here termed COG0212) of the ATP-dependent folate salvage enzyme 5-formyltetrahydrofolate cycloligase (5-FCL) occurs in all domains of life and, although typically annotated as 5-FCL in pro- and eukaryotic genomes, is of unknown function. COG0212 is similar in overall structure to 5-FCL, p...

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Detalhes bibliográficos
Publicado no:Funct Integr Genomics
Main Authors: Pribat, Anne, Blaby, Ian K., Lara-Núñez, Aurora, Jeanguenin, Linda, Fouquet, Romain, Frelin, Océane, Gregory, Jesse F., Philmus, Benjamin, Begley, Tadhg P., de Crécy-Lagard, Valérie, Hanson, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078417/
https://ncbi.nlm.nih.gov/pubmed/21538139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10142-011-0224-5
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