6-Pyruvoyltetrahydropterin Synthase Paralogs Replace the Folate Synthesis Enzyme Dihydroneopterin Aldolase in Diverse Bacteria

Dihydroneopterin aldolase (FolB) catalyzes conversion of dihydroneopterin to 6-hydroxymethyldihydropterin (HMDHP) in the classical folate biosynthesis pathway. However, folB genes are missing from the genomes of certain bacteria from the phyla Chloroflexi, Acidobacteria, Firmicutes, Planctomycetes,...

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Bibliographic Details
Main Authors: Pribat, Anne, Jeanguenin, Linda, Lara-Núñez, Aurora, Ziemak, Michael J., Hyde, John E., de Crécy-Lagard, Valérie, Hanson, Andrew D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Enzymes and Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698474/
https://ncbi.nlm.nih.gov/pubmed/19395485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00416-09
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