Telomerase reverse transcriptase coordinates with the epithelial-to-mesenchymal transition through a feedback loop to define properties of breast cancer stem cells

Telomerase and its core component, telomerase reverse transcriptase (hTERT), are critical for stem cell compartment integrity. Normal adult stem cells have the longest telomeres in a given tissue, a property mediated by high hTERT expression and high telomerase enzymatic activity. In contrast, cance...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biol Open
Prif Awduron: El-Badawy, Ahmed, Ghoneim, Nehal I., Nasr, Mohamed A., Elkhenany, Hoda, Ahmed, Toka A., Ahmed, Sara M., El-Badri, Nagwa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists Ltd 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078341/
https://ncbi.nlm.nih.gov/pubmed/29907642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.034181
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