Doxorubicin-conjugated dexamethasone induced MCF-7 apoptosis without entering the nucleus and able to overcome MDR-1-induced resistance

BACKGROUND: Doxorubicin (DOX) is the most widely used chemotherapeutic agent that has multimodal cytotoxicity. The main cytotoxic actions of DOX occur in the nucleus. The emergence of drug-resistant cancer cells that have the ability to actively efflux DOX out of the nucleus, and the cytoplasm has l...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Drug Des Devel Ther
Main Authors: Chaikomon, Kamontip, Chattong, Supreecha, Chaiya, Theerasak, Tiwawech, Danai, Sritana-Anant, Yongsak, Sereemaspun, Amornpun, Manotham, Krissanapong
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078182/
https://ncbi.nlm.nih.gov/pubmed/30122894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S168588
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker