Doxorubicin-conjugated dexamethasone induced MCF-7 apoptosis without entering the nucleus and able to overcome MDR-1-induced resistance

BACKGROUND: Doxorubicin (DOX) is the most widely used chemotherapeutic agent that has multimodal cytotoxicity. The main cytotoxic actions of DOX occur in the nucleus. The emergence of drug-resistant cancer cells that have the ability to actively efflux DOX out of the nucleus, and the cytoplasm has l...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Chaikomon, Kamontip, Chattong, Supreecha, Chaiya, Theerasak, Tiwawech, Danai, Sritana-Anant, Yongsak, Sereemaspun, Amornpun, Manotham, Krissanapong
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078182/
https://ncbi.nlm.nih.gov/pubmed/30122894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S168588
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