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Development of small-molecule therapeutics and strategies for targeting RAF kinase in BRAF-mutant colorectal cancer
RAF kinase is crucially involved in cell proliferation and survival in colorectal cancer (CRC). Patients with metastatic CRC (mCRC) harboring BRAF mutations (BRAFms) not only experience a poor prognosis but also benefit less from therapeutics targeting ERK signaling. With advances in RAF inhibitors...
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| Pubblicato in: | Cancer Manag Res |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Dove Medical Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6078078/ https://ncbi.nlm.nih.gov/pubmed/30122982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S170105 |
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