Ultrasound-Mediated Gene Therapy in Swine Livers Using Single-Element, Multi-lensed, High-Intensity Ultrasound Transducers

We have achieved significant enhancement of gene delivery into livers of large animals using ultrasound (US)-targeted microbubble (MB) destruction methods. An infusion of pGL4 (encoding a luciferase reporter gene) plasmid DNA (pDNA) and MBs into a portal-vein segmental branch of a porcine liver was...

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Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Noble-Vranish, Misty L., Song, Shuxian, Morrison, Kyle P., Tran, Dominic M., Sun, Ryan R., Loeb, Keith R., Keilman, George W., Miao, Carol H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077835/
https://ncbi.nlm.nih.gov/pubmed/30105275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.06.008
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