Ultrasound-targeted Microbubble Destruction-mediated Gene Delivery Into Canine Livers

Ultrasound (US) was applied to a targeted canine liver lobe simultaneously with injection of plasmid DNA (pDNA)/microbubble (MB) complexes into a portal vein (PV) segmental branch and occlusion of the inferior vena cava (IVC) to facilitate DNA uptake. By using a 1.1 MHz, 13 mm diameter transducer, a...

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Autors principals: Noble, Misty L, Kuhr, Christian S, Graves, Scott S, Loeb, Keith R, Sun, Samuel S, Keilman, George W, Morrison, Kyle P, Paun, Marla, Storb, Rainer F, Miao, Carol H
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776626/
https://ncbi.nlm.nih.gov/pubmed/23732985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.107
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