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Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN

Schwann cells (SCs), the glia of the peripheral nervous system, play an essential role in nerve regeneration. Upon nerve injury, SCs are reprogrammed into unique “repair SCs,” and these cells remove degenerating axons/myelin debris, promote axonal regrowth, and ultimately remyelinate regenerating ax...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kim, Sungsu, Maynard, Jason C., Strickland, Amy, Burlingame, Alma L., Milbrandt, Jeffrey
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077742/
https://ncbi.nlm.nih.gov/pubmed/30012597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805538115
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