Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure

Heart failure (HF) is a shared manifestation of several cardiovascular pathologies, including hypertension and myocardial infarction, and a limited repertoire of treatment modalities entails that the associated morbidity and mortality remain high. Impaired nitric oxide (NO)/guanylyl cyclase (GC)/cyc...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Baliga, Reshma S., Preedy, Michael E. J., Dukinfield, Matthew S., Chu, Sandy M., Aubdool, Aisah A., Bubb, Kristen J., Moyes, Amie J., Tones, Michael A., Hobbs, Adrian J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077693/
https://ncbi.nlm.nih.gov/pubmed/30012589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800996115
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