A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors

Delivering genes selectively to the therapeutically relevant cell type is among the prime goals of vector development. Here, we present a high-throughput selection and screening process that identifies designed ankyrin repeat proteins (DARPins) optimally suited for receptor-targeted gene delivery us...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Hartmann, Jessica, Münch, Robert C., Freiling, Ruth-Therese, Schneider, Irene C., Dreier, Birgit, Samukange, Washington, Koch, Joachim, Seeger, Markus A., Plückthun, Andreas, Buchholz, Christian J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077149/
https://ncbi.nlm.nih.gov/pubmed/30101151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.07.001
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