UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells

Enhanced gene transfer efficiencies and higher yields of transplantable transduced human hematopoietic stem cells are continuing goals for improving clinical protocols that use stemcell-based gene therapies. Here, we examined the effect of the HSC agonist UM171 on these endpoints in both in vitro an...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Ngom, Mor, Imren, Suzan, Maetzig, Tobias, Adair, Jennifer E., Knapp, David J.H.F., Chagraoui, Jalila, Fares, Iman, Bordeleau, Marie-Eve, Sauvageau, Guy, Leboulch, Philippe, Eaves, Connie, Humphries, Richard Keith
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077133/
https://ncbi.nlm.nih.gov/pubmed/30101153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.06.009
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