UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells

Enhanced gene transfer efficiencies and higher yields of transplantable transduced human hematopoietic stem cells are continuing goals for improving clinical protocols that use stemcell-based gene therapies. Here, we examined the effect of the HSC agonist UM171 on these endpoints in both in vitro an...

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Publicado en:Mol Ther Methods Clin Dev
Autores principales: Ngom, Mor, Imren, Suzan, Maetzig, Tobias, Adair, Jennifer E., Knapp, David J.H.F., Chagraoui, Jalila, Fares, Iman, Bordeleau, Marie-Eve, Sauvageau, Guy, Leboulch, Philippe, Eaves, Connie, Humphries, Richard Keith
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Gene & Cell Therapy 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077133/
https://ncbi.nlm.nih.gov/pubmed/30101153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.06.009
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