UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells

Enhanced gene transfer efficiencies and higher yields of transplantable transduced human hematopoietic stem cells are continuing goals for improving clinical protocols that use stemcell-based gene therapies. Here, we examined the effect of the HSC agonist UM171 on these endpoints in both in vitro an...

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Bibliografski detalji
Izdano u:Mol Ther Methods Clin Dev
Glavni autori: Ngom, Mor, Imren, Suzan, Maetzig, Tobias, Adair, Jennifer E., Knapp, David J.H.F., Chagraoui, Jalila, Fares, Iman, Bordeleau, Marie-Eve, Sauvageau, Guy, Leboulch, Philippe, Eaves, Connie, Humphries, Richard Keith
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077133/
https://ncbi.nlm.nih.gov/pubmed/30101153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.06.009
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