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Expression and Purification of Nuclease-Free Protocatechuate 3,4-Dioxygenase for Prolonged Single-Molecule Fluorescence Imaging

Single-molecule (SM) microscopy is a powerful tool capable of visualizing individual molecules and events in real time. SM imaging may rely on proteins or nucleic acids labelled with a fluorophore. Unfortunately photobleaching of fluorophores leads to irreversible loss of signal, impacting the colle...

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Pubblicato in:Anal Biochem
Autori principali: Senavirathne, Gayan, Lopez, Miguel A., Messer, Ryan, Fishel, Richard, Yoder, Kristine E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6076860/
https://ncbi.nlm.nih.gov/pubmed/29932890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2018.06.016
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