The selectivity of galardin and an azasugar-based hydroxamate compound for human matrix metalloproteases and bacterial metalloproteases

Inhibitors targeting bacterial enzymes should not interfere with enzymes of the host, and knowledge about structural determinants for selectivity is important for designing inhibitors with a therapeutic potential. We have determined the binding strengths of two hydroxamate compounds, galardin and co...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Sylte, Ingebrigt, Dawadi, Rangita, Malla, Nabin, von Hofsten, Susannah, Nguyen, Tra-Mi, Solli, Ann Iren, Berg, Eli, Adekoya, Olayiwola A., Svineng, Gunbjørg, Winberg, Jan-Olof
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2018
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6075749/
https://ncbi.nlm.nih.gov/pubmed/30075004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200237
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