The selectivity of galardin and an azasugar-based hydroxamate compound for human matrix metalloproteases and bacterial metalloproteases

Inhibitors targeting bacterial enzymes should not interfere with enzymes of the host, and knowledge about structural determinants for selectivity is important for designing inhibitors with a therapeutic potential. We have determined the binding strengths of two hydroxamate compounds, galardin and co...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sylte, Ingebrigt, Dawadi, Rangita, Malla, Nabin, von Hofsten, Susannah, Nguyen, Tra-Mi, Solli, Ann Iren, Berg, Eli, Adekoya, Olayiwola A., Svineng, Gunbjørg, Winberg, Jan-Olof
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6075749/
https://ncbi.nlm.nih.gov/pubmed/30075004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200237
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